The journey to 100 friends begins with a single conversation. Socially anxious high school student Shoko Komi's greatest dream is to make some friends, but everyone at school mistakes her crippling social anxiety for cool reserve. Luckily she meets Tadano, a timid wallflower who decides to step out of his comfort zone in order to help her achieve her goal of making 100 friends.

Komi is starting her second year of high school, and she's feeling a bit melancholy that all the good times of the previous year are now behind her. How can anything else compare? But when Komi runs into a girl in her new class with outrageous fashion sense crying in the bathroom, she's able to put all her wonderful friend-making experience to good use and reach out to another person in need. Komi has leveled up!